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NEWS: Pokemon Causes Cancer


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Joe Mello



Joined: 31 May 2004
Posts: 2312
Location: Online Terminal
PostPosted: Wed Jan 26, 2005 11:52 pm Reply with quote
Wow. I don't know where to start. Either this is a joke, a massive coincidence, or someone at the Center has a sense of humor.

I think that covers all the bases.
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mrhomiec



Joined: 15 Sep 2004
Posts: 29
Location: Arizona
PostPosted: Wed Jan 26, 2005 11:58 pm Reply with quote
what the hell??

either the person who named this is an anime freak or the person just hates pokemon that much
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darkchibi07



Joined: 15 Oct 2003
Posts: 5515
PostPosted: Wed Jan 26, 2005 11:59 pm Reply with quote
I don't know if I should be concerned or laugh. I think I'll do both.
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midori kou



Joined: 22 Oct 2004
Posts: 469
PostPosted: Thu Jan 27, 2005 12:31 am Reply with quote
Pokemon is evil after all. Anime hyper!
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dormcat
Encyclopedia Editor


Joined: 08 Dec 2003
Posts: 9902
Location: New Taipei City, Taiwan, ROC
PostPosted: Thu Jan 27, 2005 12:33 am Reply with quote
Here is the abstract of this Nature article:

Quote:
Aberrant transcriptional repression through chromatin remodelling and histone deacetylation has been postulated to represent a driving force underlying tumorigenesis because histone deacetylase inhibitors have been found to be effective in cancer treatment. However, the molecular mechanisms by which transcriptional derepression would be linked to tumour suppression are poorly understood. Here we identify the transcriptional repressor Pokemon (encoded by the Zbtb7 gene) as a critical factor in oncogenesis. Mouse embryonic fibroblasts lacking Zbtb7 are completely refractory to oncogene-mediated cellular transformation. Conversely, Pokemon overexpression leads to overt oncogenic transformation both in vitro and in vivo in transgenic mice. Pokemon can specifically repress the transcription of the tumour suppressor gene ARF through direct binding. We find that Pokemon is aberrantly overexpressed in human cancers and that its expression levels predict biological behaviour and clinical outcome. Pokemon's critical role in cellular transformation makes it an attractive target for therapeutic intervention.

The full name of Pokemon is POK erythroid myeloid ontogenic factor. Apparently the first author, Dr. Takahiro Maeda, MD, PhD, is an anime lover and has a great sense of humor. PM me if you want to learn further about Pokemon's mechanism.

By the way, this Pokemon protein has nothing to do with photosensitive epilepsy caused by episode 38.

I never imagine to have a chance discussing about those topics at ANN. Anime smile
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Bulghod



Joined: 19 Jan 2005
Posts: 36
Location: CT
PostPosted: Thu Jan 27, 2005 12:39 am Reply with quote
I KNEW IT!
wow, i've been saying this for like 2 years. i can't believe it's actually true. first seizures, now this. Pokemon will be one of the factors in the downfall of society.
psycho anime theories=3
reality=300
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darkhunter



Joined: 13 May 2004
Posts: 2992
Location: Los Angelas
PostPosted: Thu Jan 27, 2005 1:07 am Reply with quote
So many pokemon hater on this board. Pokemon is for kids.....kidsssssssssss. Stop hating on kids show, unless you are one.

Poekmon Causes Cancer?
Somehow, the lingo "Gotta catch'em all" comes to mind.
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Colonel Wolfe



Joined: 05 Aug 2004
Posts: 370
PostPosted: Thu Jan 27, 2005 1:25 am Reply with quote
The Admin of ANN should have shown a little more caution when posting about this one. You would think that a site as professional as ANN would have shown more common sense than trying to be funny about a disease that isn't funny.

More to the fact ... blasting a dedicated anime show that continues to be popular among its fans when the disease has NOTHING to do with the anime is also a lack of responsibility on the part of ANN.

I'm very disappointed.
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Erufu



Joined: 06 Jul 2004
Posts: 191
PostPosted: Thu Jan 27, 2005 1:38 am Reply with quote
I think it's hilarious how the headline is entitled. I'm sure it came in on a google news search or something for anime. That's just funny. And I love the slogan comment.
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Trident



Joined: 15 Jun 2004
Posts: 13
PostPosted: Thu Jan 27, 2005 1:52 am Reply with quote
Colonel Wolfe wrote:
I'm very disappointed.


Due to the nature of your response I'm guessing either you have no sense of humor or you've had a close personal experience with cancer, probably recently. If it's the former case, then lighten up a little--although you're absolutely correct in stating that this article has nothing to do with anime, it is still something that many fans would find enjoyable and humorous in an ironic sense. Most of the Pokemon fans who frequent this site enjoy the series as a guilty pleasure, like a tub of Ben and Jerry's Ice Cream or a large slab of chocolate or a bag of popcorn when you're at the movies. I don't think I know of anyone personally who would take offense at this article or find it as degrading towards the series. In fact, it demonstrates the growing popularity of anime more than anything else.

If the latter case is true--if you're dealing with/have recently dealt with cancer--well, I summon as much sympathy as a complete stranger over the internet possibly can. If I knew you personally I'd probably give you a big hug and offer you a shoulder to cry on. However, I don't, so instead of relying on the collective sympathies of complete strangers, you should talk to one of your friends--someone who at least knows what's going on in your life and is willing to help you and be there for you.
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Proman



Joined: 19 Nov 2003
Posts: 947
Location: USA
PostPosted: Thu Jan 27, 2005 1:57 am Reply with quote
While I do think that this is funny I don't think that Nintendo might not be to happy to see one of it's most popular licenses being associated with cancer. I wouldn't blame them if they did.
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dormcat
Encyclopedia Editor


Joined: 08 Dec 2003
Posts: 9902
Location: New Taipei City, Taiwan, ROC
PostPosted: Thu Jan 27, 2005 2:31 am Reply with quote
Proman wrote:
While I do think that this is funny I don't think that Nintendo might not be to happy to see one of it's most popular licenses being associated with cancer. I wouldn't blame them if they did.

Sonic (the) Hedgehog is an important signaling molecule in neuronal development discovered by a research group at Harvard more than 11 years ago (Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30). Recent investigations also have shown its relationships with pancreatic cancer (Cengel KA. Targeting Sonic Hedgehog: a new way to mow down pancreatic cancer? Cancer Biol Ther. 2004 Feb;3(2):165-6). Never heard SEGA complained. Wink

Another good example is small ubiquitin-like modifier (SUMO). You can see comical sumo wrestler figures everywhere in SUMO-related conferences. Neither did Nihon Sumo Kyokai (日本相撲協会) complained.

Colonel Wolfe, I personally admire Dr. Maeda's sense of humor. If his nomenclature hurts your feelings, please contact him or his boss directly.


Last edited by dormcat on Thu Jan 27, 2005 2:34 am; edited 1 time in total
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Mohawk52



Joined: 16 Oct 2003
Posts: 8202
Location: England, UK
PostPosted: Thu Jan 27, 2005 2:31 am Reply with quote
Alcohol, tobacco, firearms, and now pokémon. I always knew they were hazardous to health. Laughing
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Emerje



Joined: 10 Aug 2002
Posts: 7413
Location: Maine
PostPosted: Thu Jan 27, 2005 2:37 am Reply with quote
Heh, I'll be laughing about this for a while. It's good to have a fun post once in a while, certianly made my day. Very Happy

Emerje
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WaR.KiN



Joined: 26 Mar 2004
Posts: 68
PostPosted: Thu Jan 27, 2005 3:10 am Reply with quote
Did I hear trademark infringement?
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